MovDisordV3, Main, Exploration, bibRecord, 001A33

Restoration of motor inhibition through an abnormal premotor‐motor connection in dystonia

Identifieur interne : 001A33 ( Main/Exploration ); précédent : 001A32; suivant : 001A34

Restoration of motor inhibition through an abnormal premotor‐motor connection in dystonia

Auteurs : Ying-Zu Huang [Taïwan] ; John C. Rothwell [Royaume-Uni] ; Chin-Song Lu [Taïwan] ; Jiunjie Wang [Taïwan] ; Rou-Shayn Chen [Taïwan]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-04-30.

RBID : ISTEX:64731DEA0D2C1ADA018A1ADBE6B63D904F248232

Descripteurs français

Pascal (Inist)
- Dystonie, Pathologie du système nerveux, Restauration, Sursaut.

English descriptors

KwdEn :
- Adult, Analysis of Variance, Biophysics, Burst, Dystonia, Dystonia (genetics), Dystonia (pathology), Dystonia (therapy), Dystonic Disorders (pathology), Dystonic Disorders (therapy), Electric Stimulation (methods), Electromyography (methods), Evoked Potentials, Motor (physiology), Female, Hand (innervation), Humans, Male, Middle Aged, Molecular Chaperones (genetics), Motor Cortex (physiopathology), Nervous system diseases, Neural Inhibition (physiology), Premotor, Restoration, TBS, Transcranial Magnetic Stimulation, Treatment Outcome, Writing, dystonia, rTMS, theta burst.
MESH :
- chemical , genetics : Molecular Chaperones.
- genetics : Dystonia.
- innervation : Hand.
- methods : Electric Stimulation, Electromyography.
- pathology : Dystonia, Dystonic Disorders.
- physiology : Evoked Potentials, Motor, Neural Inhibition.
- physiopathology : Motor Cortex.
- therapy : Dystonia, Dystonic Disorders.
- Adult, Analysis of Variance, Biophysics, Female, Humans, Male, Middle Aged, Transcranial Magnetic Stimulation, Treatment Outcome, Writing.

Abstract

To clarify the rationale for using rTMS of dorsal premotor cortex (PMd) to treat dystonia, we examined how the motor system reacts to an inhibitory form of rTMS applied to the PMd in healthy subjects and in a group of patients with focal hand dystonia and DYT1 gene carriers. Continuous theta burst transcranial magnetic stimulation (cTBS) with 300 and 600 pulses (cTBS300 and cTBS600) was applied to PMd, and its after‐effects were quantified by measuring the amplitude of MEPs evoked by single pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1), short interval intracortical inhibition/facilitation (SICI/ICF) within M1, the third phase of spinal reciprocal inhibition (RI), and writing tests. In addition, in DYT1 gene carriers, the effects of cTBS300 over M1 and PMd on MEPs were studied in separate experiments. In healthy subjects, cTBS300 and cTBS600 over PMd suppressed MEPs for 30 min or more and cTBS600 decreased SICI and RI. In contrast, neither form of cTBS over PMd had any significant effect on MEPs, while cTBS600 increased effectiveness of SICI and RI and improved writing in patients with writer's cramp. NMDYT1 had a normal response to cTBS300 over left PMd. We suggest that the reduced PMd to M1 interaction in dystonic patients is likely to be due to reduced excitability of PMd‐M1 connections. The possible therapeutic effects of premotor rTMS may therefore involve indirect effects of PMd on SICI and RI, which this study has shown can be normalised by cTBS. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.22814

Affiliations:

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<term>Dystonia (genetics)</term>
<term>Dystonia (pathology)</term>
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<term>Molecular Chaperones (genetics)</term>
<term>Motor Cortex (physiopathology)</term>
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<term>Restoration</term>
<term>TBS</term>
<term>Transcranial Magnetic Stimulation</term>
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<front><div type="abstract" xml:lang="en">To clarify the rationale for using rTMS of dorsal premotor cortex (PMd) to treat dystonia, we examined how the motor system reacts to an inhibitory form of rTMS applied to the PMd in healthy subjects and in a group of patients with focal hand dystonia and DYT1 gene carriers. Continuous theta burst transcranial magnetic stimulation (cTBS) with 300 and 600 pulses (cTBS300 and cTBS600) was applied to PMd, and its after‐effects were quantified by measuring the amplitude of MEPs evoked by single pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1), short interval intracortical inhibition/facilitation (SICI/ICF) within M1, the third phase of spinal reciprocal inhibition (RI), and writing tests. In addition, in DYT1 gene carriers, the effects of cTBS300 over M1 and PMd on MEPs were studied in separate experiments. In healthy subjects, cTBS300 and cTBS600 over PMd suppressed MEPs for 30 min or more and cTBS600 decreased SICI and RI. In contrast, neither form of cTBS over PMd had any significant effect on MEPs, while cTBS600 increased effectiveness of SICI and RI and improved writing in patients with writer's cramp. NMDYT1 had a normal response to cTBS300 over left PMd. We suggest that the reduced PMd to M1 interaction in dystonic patients is likely to be due to reduced excitability of PMd‐M1 connections. The possible therapeutic effects of premotor rTMS may therefore involve indirect effects of PMd on SICI and RI, which this study has shown can be normalised by cTBS. © 2010 Movement Disorder Society</div>
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Movement Disorders (revue)

Restoration of motor inhibition through an abnormal premotor‐motor connection in dystonia

Restoration of motor inhibition through an abnormal premotor‐motor connection in dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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